The neighborhood is zoned to Houston ISD schools, including Poe Elementary School (located in Boulevard Oaks), Lanier Middle School (located in Montrose), and Lamar High School (located in Upper Kirby).
A private school called the Southampton Montessori School is also located in the neighborhood.
Homes in Southampton, always expensive by Houston standards, have increased considerably in value in the past several years, to a neighborhood-wide average in 2006 of around $250 per square foot of structure area. Land values in the best locations in the neighborhood (e.g. Sunset Blvd, Rice Blvd) are nearing $100 per square foot, rivaling the most expensive areas of West University Place, and River Oaks. Aside from many interesting and luxurious new residences, Southampton was originally filled with many excellent examples of Tudor-style homes. The brooding brick buildings and lush oak canopy give Southampton a "college town" feel, congruent with nearby Rice University.